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. Author manuscript; available in PMC: 2014 Mar 25.
Published in final edited form as: Behav Brain Res. 2012 Apr 9;232(1):98–113. doi: 10.1016/j.bbr.2012.04.001

Fig. 4.

Fig. 4

Effect of rottlerin (A, C, E, and G) or PKCδ gene knockout (B, D, F, and H) on changes in dopamine (A and B), 3,4-dihydroxyphenylacetic acid (DOPAC; C and D), homovanillic acid (HVA; E and F), and the dopamine turnover rate (G and H) in the mouse striatum 3 d and 14 d after the final methamphetamine (MA) administration. Sal = Saline. Vehicle (10% DMSO) = Veh. Rott 1.5 or Rott 3.0 = rottlerin, a PKCδ inhibitor at a dose of 1.5 or 3.0 μg, i.c.v.. Each value is the mean ± standard error of the mean (S.E.M.) of six animals. *P < 0.05, **P < 0.01 vs. corresponding saline-treated mice. #P < 0.05, ##P < 0.01 vs. Veh + MA- or MA-treated PKCδ (+/+) mice (one-way ANOVA followed by Fisher's PLSD test).