Table 2.
Genetic Evidence of Association of GLO-1 and Anxiety-related Disorders
| Species | Behavioral Assessment | Genes | Reference | Observations |
|---|---|---|---|---|
| Humans | DSM-IV criteria for panic disorder | GLO1 | Politi et al., 2006 | Ala111Glu polymorphism of GLO1 gene |
| Mice | OF Light/dark test |
GLO1 and GSR1 | Hovatta et al., 2005 | — |
| Mice | OF | GLO1 | Benton et al., 2011 | — |
| Mice | EPM | GLO1* | Ditzen et al., 2006 | HAB and LAB mice Red blood cells and amygdaloid expression measures |
| Mice | OF Open-arm exposure test Light/dark test USV test |
GLO1* | Kromer et al., 2005 | HAB and LAB mice |
| Rats and Mice | AVP and GLO1* | Landgraf et al., 2007 | HAB and LAB mice | |
| Mice | OF | GLO1 | Williams et al., 2007 | Inbred, CD1 and wildtype mice were analyzed; whole brain and amygdaloid complex were analyzed |
| Humans | GLO1 | Ranganathan et al., 1999 | — | |
| Rats | OF Light/dark test |
GLO1 and GSR1 | Vollert et al., 2011 | Hippocampus, cortex, and amygdala gene expression analyzed Anxiety-like behavior provoked by sleep deprivation |
AVP, arginine vasopressin; DSM-IV, Diagnostic and Statistical Manual of Mental Disorders, 4th edition; EPM, elevated plus maze; HAB, High Anxiety Behavior; LAB, Low Anxiety Behavior; OF, open field; USV, ultrasonic vocalization.