Figure 3. Biophysical model of intestinal stem cell dynamics.

a, From the unfolded crypt caricature (left), we synthesize a quasi-one-dimensional biophysical model of the niche region (right) consisting of two domains: border and centre. To conserve cell number, cell rearrangements following stem cell division displace precisely one cell from the border. To capture the range of lineage data, we include 5 channels of stem cell loss/replacement (1-5) defined in the main text. b, Cumulative size distributions of clones derived from a single cell in the centre (left) or border (right). Clone size is defined in both cases by total number of constituent cells in centre and border. Error bars represent s.e.m. Points represent predictions of the model using the same parameters as that inferred from the average dependences (Supplementary Notes).