Figure 6. Correlated neuron-groups are spatially re-distributed during trace conditioning.
(A and B) Sample trace-conditioned (A) and pseudo-conditioned (B) mouse neuron-clusters, identified in early (left), middle (center) and late (right) trials, for pre-training (top) as well as training (bottom) sessions. Neurons have been color-coded as per the noise-correlation cluster they belong to, and cluster numbers have been sorted for maximum cluster member overlap across trial-groups. (C) Spatial organization of correlated cell-clusters changes during learning. Summarized statistical testing of stability of clusters over the training session. A cluster similarity score (SS) was computed to measure the similarity between clusters from different parts of the session. Mean similarity scores for clusters of neurons from trace conditioned mice are shown in blue, pseudo-conditioned mice in green, and non-learners in cyan. Pre-training session scores are displayed as hatched bars and training session scores, solid bars. Error-bars denote SEM. The black, dotted line denotes chance level overlap score, and the red, dotted line indicates mean overlap score with perfectly overlapping clusters (* indicates p<0.01).