Table 1. Summary of Results for All Photolysis Experiments.
peptide |
||||||
---|---|---|---|---|---|---|
phase | λ (nm) | t (min) | Aβ16–22 | Aβ16–22TFMD20 | Aβ16–22PA20 | Aβ16–22BP20 |
solution | 254 | 5 | NDa | ND | partial photolysis; appearance of HFIP adduct and other insertion products | no changeb |
60 | no change | ND | photolysis nearing completion; HFIP adduct is the dominant product; homodimer observed | ND | ||
365 | 5 | ND | partial photolysis; appearance of HFIP adduct and cyclized monomer | ND | no change | |
60 | no change | complete photolysis; HFIP adduct is the dominant product | ND | no change | ||
homoaggregate | 254 | 60 | ND | ND | complete photolysis; putative oxidation products dominate | ND |
365 | 60 | no change28 | complete photolysis; peptide insertion products dominate | ND | homodimer observed in dark control | |
heteroaggregate | 254 | 60 | NAc | ND | heterodimer observed | ND |
365 | 60 | NA | heterodimer observed | ND | heterodimer observed in dark control |
ND = no data.
All changes reported are relative to a dark control.
NA = not applicable.