Table 2.

Meta-analyses of baseline volumetric differences between schizophrenia patients and healthy controls. Negative values of Hedge’s g indicate reduced volume in patients vs. controls.

Brain region	N	SCZ	C	Hedge’s g			Z score	p	Test for Heterogeneity			FSN	ERT	Trimm and Fill
				Mean	CI95%				Q	I2	p			Mean	CI95%
WBV	11	581	429	−0.252	−0.414	−0.091	−3.063	0.002*	13.561	26.26	0.194	27	0.411	−0.252	−0.414	−0.091
GMV	8	399	382	−0.192	−0.343	−0.041	−2.493	0.013	3.635	3.7	0.821	18	0.111	−0.192	−0.343	−0.041
WMV	6	199	261	−0.012	−0.294	0.269	−0.087	0.931	8.717	42.64	0.121	0	0.393	−0.012	−0.294	0.269
CSF	3	60	98	0.451	0.088	0.813	1.434	0.045	2.173	7.90	0.337	3	0.069	0.325	−0.037	0.686
LV	11	549	347	0.309	0.144	0.467	4.046	<0.001*	12.084	17.25	0.279	44	0.139	0.309	0.144	0.467
Cd	9	192	171	0.116	−0.107	0.339	1.020	0.308	8.589	6.85	0.378	0	0.592	0.116	−0.107	0.339

WBV, whole brain volume; GMV, grey matter volume; WMV, white matter volume; CSF, cerebrospinal fluid; LV, lateral ventricules; Cd, Caudate nucleus; N = number of studies included in each meta-analysis; SCZ, number of patients with schizophrenia; C, number of controls;

^*Surviving correction for multiple comparisons (p = 0.008);

FSN, Fail Safe Number; ERT, Egger’s Regression Test.