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Analysis of IL-21-producing cells by ICS. The frequencies of IL-21-secreting CD4+ T cells in the CHB, HB-ACLF and cirrhosis groups are compared with the HC group. Gated on lymphocytes. A, CHB; B, HB-ACLF; C, cirrhosis; D, HC; ICS, intracellular cytokine staining; CHB, chronic hepatitis B; HB-ACLF, hepatitis B-related acute-on-chronic liver failure; HC, healthy controls; IL-21, interleukin-21.
