Table 1.

Comparison of SMPDB 2.0 to SMPDB 1.0 to KEGG, HumanCyc, Reactome, BioCarta and WikiPathways/GenMAPP

Feature	SMPDB 2.0	SMPDB 1.0	KEGG	Reactome	HumanCyc	BioCarta	WikiPathways
Number of metabolic pathways	92	70	78 (for humans)	64 (for humans)	333 (short pathways)	69	50 (for humans)
Number of disease pathways	221	113	52	11	0	24	16
Number of drug action pathways	232	168	0	3	3	10	5
Number of drug metabolism pathways	53	0	8	1	0	0	2
Number of physio. action pathways	5	0	31	36	0	5	22
Number of small mol. signaling pathways	15	0	30	27	0	30	15
Provides multiple organism pathways	No	No	Yes	Yes	No	Yes	Yes
Chemical structures shown in diagrams	Yes	Yes	No	No	Yes (when zoomed)	Some	No
Protein 4o structures shown in diagrams	Yes	Yes	No	No	No	Some	No
Cell structures shown in pathway diagrams	Yes	Yes	Some	Yes	No	Yes	No
Organs shown in pathway diagrams	Most	Some	No	No	No	No	No
Descriptions of pathways provided	Detailed	Detailed	Limited	Detailed	Detailed	Detailed	Limited
Pathway images are hyperlinked	Yes	Yes	Yes	Yes	Yes	Yes	No
Pathway images are easily zoomable	Yes	No	No	Yes	Yes	No	Limited
Information provided on pathway entities	Detailed	Detailed	Modest	Modest	Moderate	Limited	Limited
Supports advanced text search	Yes	Yes	No	Yes	Yes	No	No
Supports sequence searching	Yes	Yes	No	No	Yes	No	No
Supports graphical chem. structure search	Yes	Yes	No	No	No	No	No
Supports chemical expression mapping	Yes	Yes	Yes	Yes	Yes	No	No
Supports gene/protein expression mapping	Yes	Yes	Yes	Yes	Yes	No	No
Downloadable	Yes	Yes	Limited	Yes	Yes	No	Yes
BioPax, CellML or SBML compatible	Yes	No	Partial	Yes	Yes	No	No