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. 2013 Nov 29;42(Database issue):D206–D214. doi: 10.1093/nar/gkt1226

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — The ‘Compare Regions’ tool in the SEED. The Staphylococcal SCCmec element is shown as an example. Re-arrangements within Staphylococcal SCCmec element lead to constitutive expression of resistance determinant MecA due to (partial) deletion of repressor MecI and/or sensor-transducer MecR. Homologous genes are presented as arrows with matching colors and numbers. Genes not conserved within the displayed region are gray. The graphic is centered on the focus gene (red, #1): Methicillin resistance determinant MecA; green, #8: Methicillin resistance regulatory sensor-transducer MecR1; blue, #18: Methicillin resistance repressor MecI; green, #2: transposase for IS431.