Figure 1.

Errors identified during benchmarking. We detected errors in 70 manually curated domains by running benchmarking and manually inspecting predicted domains that did not sufficiently match the manually annotated domains. These errors in domain boundaries in multi-domain chains were manually fixed in SCOPe 2.03. We also detected and fixed inconsistencies in 5054 domains that had been predicted and classified with the SCOP 1.73 automated method. We review some of the types of errors detected. (a) The SCOP 1.73 automated method used to predict domain d2p8qa1 had included approximately half the residues in the chain. This was inconsistent with all other manually curated entries in its species-level clade that included the entire chain. (b) A strand of beta sheet was included in the d1tqya2 domain by manual curation. (c) All of chain I from 1oyv had been placed into a single domain. (d) The manually curated domain d1seja2 excluded the first helix in the chain.