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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Free Radic Biol Med. 2013 Sep 19;65:1201–1208. doi: 10.1016/j.freeradbiomed.2013.09.008

Figure 3. Sensitivity of pyruvate-supported JH2O2 to GSH depletion across species.

Figure 3

Permeabilized fiber bundles were prepared from RG muscle of C57BL/6N mice (A), Sprague Dawley rats (B) or vastus lateralis muscle of human subjects (C). Fibers were pre-treated with varying concentrations of CDNB and pyruvate [1mM] supported H2O2 emission was then assessed. GSH was assessed as described in figure 2B for each species. Data are presented as % change from ethanol control. *Different from 0μM condition (p <0.05). Data are mean ± SEM, n = 4-6/group.