. 2013 Dec 2;32(10):997–1005. doi: 10.1200/JCO.2013.52.0536

Table 1.

Baseline Patient Characteristics

Characteristic	CaMg Before and After Chemotherapy (n = 118)					CaMg Before and Placebo After Chemotherapy (n = 116)					Placebo (n = 119)					Total (n = 353)					P
Characteristic	No.	%	Mean	SD	Median	No.	%	Mean	SD	Median	No.	%	Mean	SD	Median	No.	%	Mean	SD	Median
Age, years					57.0					57.0					56.0					56.0	.9058^*
Age group < 65 years	88	75				87	75				90	76				265	75				.9823^†
Male sex	56	48				56	48				57	48				169	48				.9922^†
Race/ethnicity																					.4543^‡
White	96	81				99	85				105	88				300	85
Black or African American	16	14				15	13				10	8				41	12
Asian	4	3				1	1				2	2				7	2
American Indian or Alaska Native	2	2				0	0				1	1				3	1
Not reported (patient refused or not available)	0	0				1	1				1	1				2	1
Stage																					.9627^†
II	22	19				22	19				22	19				66	19
III	89	75				88	76				88	74				265	75
IV	7	6				6	5				9	8				22	6
Regimen																					.9394^†
FOLFOX4	7	6				8	7				9	8				24	7
mFOLFOX6	111	94				108	93				110	92				329	93
Oral CaMg supplement																					.9709^†
Missing	2					0					3					5
Yes	12	10				13	11				13	11				38	11
No	104	90				103	89				103	89				310	89
Total EORTC QLQ-CIPN20 score
Sensory neuropathy			98.4	4.0	100.0			97.6	5.9	100.0			97.8	6.4	100.0			97.9	5.5	100.0	.2654^*
Autonomic neuropathy			95.0	10.1	100.0			92.3	12.6	100.0			91.8	13.0	100.0			93.0	12.0	100.0	.1155^*
Motor neuropathy			97.9	3.9	100.0			97.0	7.7	100.0			98.0	3.9	100.0			97.6	5.5	100.0	.9789^*
Sensitivity to touching cold items			95.9	14.2	100.0			94.4	17.0	100.0			96.0	14.5	100.0			95.4	15.3	100.0	.3876^*
Discomfort swallowing cold liquids			96.2	13.4	100.0			92.6	18.9	100.0			94.2	17.7	100.0			94.4	16.8	100.0	.1173^*
Throat discomfort			97.1	11.1	100.0			93.7	17.5	100.0			96.0	13.4	100.0			95.6	14.3	100.0	.2685^*
Muscle cramps			97.9	8.6	100.0			97.5	8.9	100.0			96.8	11.4	100.0			97.4	9.7	100.0	.5322^*
Difficulties buttoning/tying			99.7	2.1	100.0			98.8	5.9	100.0			99.8	1.3	100.0			99.5	3.7	100.0	.0930^*

Abbreviations: CaMg, calcium and magnesium; EORTC QLQ-CIPN20, European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Chemotherapy-Induced Peripheral Neuropathy 20; FOLFOX4, fluorouracil, leucovorin, and oxaliplatin; mFOLFOX6, modified fluorouracil, leucovorin, and oxaliplatin; SD, standard deviation.

Kruskal-Wallis test.

^†

χ² test.

^‡

Fisher's exact test.