TABLE III.
Weight change and risk of colon cancer from 1990 to 2004
| Updated weight change (lagged 2–4 years)1 |
Increase 4.54 kg | p-value | ||||||
|---|---|---|---|---|---|---|---|---|
| < −4 kg | −4 to −1.1 kg | −1 to 1 kg | 1.1–4 kg | 4.1–7 kg | >7 kg | |||
| Cases/person-years | 38/35,709 | 98/87,410 | 212/200,702 | 137/131,925 | 40/37,148 | 15/11,048 | 540/503,942 | |
| Age-adjusted HR2 | 0.98 (0.69–1.38) | 0.97 (0.76–1.23) | 1.00 (ref) | 1.11 (0.89–1.38) | 1.19 (0.85–1.68) | 1.70 (1.00–2.87) | 1.12 (0.99–1.28) | 0.08 |
| Multivariate adjusted HR3 | 0.82 (0.57–1.17) | 0.90 (0.71–1.15) | 1.00 (ref) | 1.07 (0.86–1.33) | 1.05 (0.75–1.49) | 1.46 (0.86–2.50) | 1.14 (1.00–1.29) | 0.04 |
1
Weight change between two consecutive weight measures two years apart on risk of colon cancer 2–4 years later, i.e., weight change between 1986–1988 on risk of colon cancer 1990–92, weight change 1988–1990 on risk 1992–94, etc.
2
HR, hazard ratio. Numbers in parentheses are 95% confidence interval.
3
Adjusted for cumulative average body mass index, physical activity, alcohol intake, folate, methionine, vitamin D, calcium, calories, processed and red meat and updated smoking habit, multivitamin use, aspirin use, endoscopic screening and family history of colorectal cancer. Confounder information was lagged four years, i.e., before weight change.