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Dietary change alters composition and function of HUM mouse microbiota. (a) Principal co-ordinate analysis (PCOA) plot of 16S rRNA-based gut microbial profiling from HUM mice fed a regular diet (RD) or polysaccharide-deficient diet (PDD; n=3 mice per group). (b) PCA plot of fecal metabolite profiling from HUM mice fed with two different diets. (c) Hierarchical clustering of fecal metabolomes from HUM mice fed with two different diets versus metabolomes of the respective mouse diets.
