Table 2. Disease and pathway enrichment, p values and genes.
| DISEASE | ||
|---|---|---|
| GeneCards (diabetes mellitus) | GeneCards (niddm) | |
| Arsenic | 5.281e-06 | 0.0076 |
| (9 genes: GCK;HMOX1;LEP;LEPR;NFKB1;PPARA;TNFRSF1A;CAT;ADIPOQ) | (7 genes: PPARGC1A;GCK;LEP;LEPR;PPARA;CAT;ADIPOQ) | |
| PFOA | 2.451e-08 | 2.824e-09 |
| (12 genes: CPT1A;GCK;HMOX1;LEPR;NFKB1;PPARA;PPARG;SLC2A2;TNFRSF1A;C3;UCP2;CAT) | (13 genes: PPARGC1A;CPT1A;GCGR;GCK;GCKR;GPD2;LEPR;LIPC;PPARA;PPARG;SLC2A2;UCP2;CAT) | |
| TCDD | 1.904e-19 | 2.785875e-18 |
| (26 genes: CPT1A;EDN1;AKT2;GCK;HMOX1;HNF4A;HP;IRS1;KCNJ11;LEP;LEPR;NFKB1;ENPP1;PPARA;PPARG;RETN;PTPN1;SLC2A1;SLC2A2;SLC2A4;TNFRSF1A;C3;UCP2;WFS1;CAT;ADIPOQ) | (26 genes: PPARGC1A;CPT1A;EDN1;GCK;GCKR;GPD2;HNF4A;IRS1;KCNJ11;LEP;LEPR;LIPC;PAX4;ENPP1;PPARA;PPARG;RETN;PTPN1;SLC2A1;SLC2A2;SLC2A4;TCF7L2;UCP2;CAT;IRS2;ADIPOQ) | |
| HCB | 0.017 | n.s. |
| (5 genes: HMOX1;HP;IRS1;TNFRSF1A;CAT) | (3 genes: IL6;IRS1;CAT) | |
Values = p-values corrected.
n.s. = p-val no significant n.d. = no data, no gene from HCB are associated to reactome/diabetes pathway.