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Kinetic apparent parameters of 125I-Aβ40 disposition by hCMEC/D3 and bEnd3 cells estimated from mechanistic model.
| Parameter | hCMEC/D3 | bEnd3 | ||
|---|---|---|---|---|
|
| ||||
| Estimate | CV% | Estimate | CV% | |
| Km, uptake (nM) | 49.1 | 0.1 | 19.8 | 14.3 |
| Vmax, uptake (fmole/min) | 4.0 | 0.01 | 56.4 | 3.9 |
| Intrinsic uptake (nl/min) | 81 | 2848 | ||
| Km, efflux (nM) | 7.5 | 17.4 | 7.6 | 22.7 |
| Vmax, efflux (fmole/min) | 0.12 | 12.2 | 0.14 | 17.1 |
| Intrinsic efflux (nl/min) | 16 | 18 | ||
| CL (nl/min) | 17 | 4.5 | 260 | 5 |
