Table 2. Mean Risk Index Scores at Randomization in 324 patients from OPTIMA.
| Patients per Category | Mean Score (SD) | ||
| Number (%) | Restricted Index | VACS Index | |
| Age (years) | 10.7 (12.9) | 5.7 (7.1) | |
| <50 | 184 (56.8) | ||
| 50 to 64 | 128 (39.5) | ||
| ≥65 | 12 (3.7) | ||
| CD4 (cells/mm3) | 27.2 (15.0) | 16.8 (10.3) | |
| ≥500 | 2 (0.6 ) | ||
| 200 to 499 | 83 (25.6) | ||
| 100 to 199 | 102 (31.5) | ||
| 50 to 99 | 44 (13.6) | ||
| <50 | 93 (28.7) | ||
| HIV-1 RNA (copies/ml) | 16.0 (6.9) | 9.5 (3.5) | |
| <500 | 2 (0.6 ) | ||
| 500 to 1×105 | 204 (63.0) | ||
| ≥1×105 | 118 (36.4) | ||
| Hemoglobin (g/dL) | 7.3 (8.6) | ||
| ≥14 | 152 (41.7) | ||
| 12 to 13.9 | 130 (40.1) | ||
| 10 to 11.9 | 34 (10.5) | ||
| <10 | 8 (15.7) | ||
| FIB-4 | 6.5 (8.5) | ||
| <1.45 | 135 (41.7) | ||
| 1.45 to 3.25 | 138 (42.6) | ||
| >3.25 | 51 (15.7) | ||
| eGFR mL/min | 0.7 (3.5) | ||
| ≥60 | 305 (94.1) | ||
| 45 to 59.9 | 3 (0.9) | ||
| 30 to 44.9 | 11 (3.4) | ||
| <30 | 5 (1.5) | ||
| Hepatitis C Infection | 1.2 (2.1) | ||
| Present | 76 (23.5) | ||
| Absent | 148 (76.5) | ||
| Total Score | 53.9 (20.5) | 42.0 (20.3) | |
| Min-Max Range | 21–115 | 13–110 | |
FIB4: (years of age×AST)/(platelets in 109/L×square root of ALT).
ALT: alanine transaminase.
AST: aspartate transaminase.
eGFR: 186.3×(serum creatinine−1.154)×(age−0.203)×(0.742 for women×(1.21 if black).