Table 3. Association Between Subsequent Mortality and Change in Score from Baseline (Randomization) to 48 Weeks, Adjusted for Baseline VACS Index Score.

		At Risk	Died	% Died	HR	LCL	UCL	p
Restricted Index Change
	Baseline VACS Index (per 5 points)				1.30	1.23	1.37	<.0001
Best 25%	<−11	73	16	22%	0.39	0.22	0.70	0.001
Central 50% (Reference)	−11 to 0	164	49	30%	1.00
Worst 25%	>0	60	21	35%	1.51	0.90	2.53	0.12
VACS Index Change
	Baseline VACS Index (per 5 points)				1.33	1.26	1.40	<0.0001
Best 25%	<−11	74	13	18%	0.26	0.14	0.40	<0.0001
Central 50% (Reference)	−11 to 9	156	46	29%	1.00
Worst 25%	>9	67	27	40%	2.08	1.27	3.38	0.003

Change in index score from baseline was assessed for 297/324324 patients surviving to 48 weeks. Risk of subsequent death was assessed by quartile with the central 50% serving as the reference group.