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. 2014 Mar 25;9(3):e92647. doi: 10.1371/journal.pone.0092647

Figure 2. The metabolic data and findings of albuminuria in streptozotocin (STZ)-treated diabetic Pemt+/+ and Pemt−/− C57BL/6JJcl mice.

Figure 2

The Pemt+/+ and Pemt−/− mice were treated with citrate buffer (CON) or streptozotocin (STZ). a. Body weight (g), b. kidney weight (g), c. kidney/body weight, d. blood glucose levels (mg/dl), e. urine volume (ml/day), f. albumin level (mg/gCr) and g. serum homocysteine level (μmol/l). The daily albumin excretion and serum homocysteine levels were significantly reduced in Pemt−/− (STZ) mice compared with Pemt+/+ (STZ) mice. h. The phosphatidylethanolamine (PE) and phosphatidylcholine (PC) contents were measured in the kidney tissues by thin-layer chromatography. The PC/PE ratio was significantly increased in Pemt−/− (STZ) compared with Pemt−/− (CON) mice; however, there was no statistically significant difference between the Pemt−/− (STZ) and Pemt+/+ (STZ) mice. ##P<0.01 v.s. Pemt+/+ (CON). **P<0.01, *P<0.05 v.s. Pemt+/+ (STZ).