Table 1. Characteristics of patients with Graves disease.

		Graves disease, goiter grade
Characteristic	Case number	0	1a	1b	2	3	P value
Female gender [n (%)]	381	28	22	43	242	46	0.513
	(79.2)	(87.5)	(84.6)	(79.6)	(79.1)	(73.0)
Age [year, median (range)]	42.0	46.0	51.5	40.9	42.0	37.0	0.001
	(17–87)	(27–77)	(28–71)	(23–75)	(17–87)	(17–77)
With cigarette smoking history [n (%)]	122	5	7	12	67	21	0.270
	(23.3)	(15.6)	(26.9)	(22.2)	(21.9)	(33.3)
With radioiodine treatment [n (%)]	21	7	2	1	9	2	2.281×10−5
	(4.4)	(21.9)	(7.7)	(1.9)	(2.9)	(3.2)
With thyroid gland surgery [n (%)]	48	20	1	3	21	3	5.887×10−22
	(10.0)	(62.5)	(3.8)	(5.6)	(6.9)	(4.8)
With ophthalmopathy [n (%)]	202	14	5	22	131	30	0.164
	(42.0)	(43.8)	(19.2)	(40.7)	(42.8)	(47.6)
With nodular hyperplasia [n (%)]	4	1	5	34	5	4	0.733
	(12.5)	(3.8)	(9.3)	(11.1)	(7.9)	(12.5)
With myxedema [n (%)]	6	0	0	2	2	2	0.188
	(1.2)	(0.0)	(0.0)	(3.7)	(0.7)	(3.2)
With vitiligo [n (%)]	4	0	2	1	1	0	0.002
	(0.8)	(0.0)	(7.7)	(1.9)	(0.3)	(0.0)