Table 3. Distributions of alleles and genotypes of the MIF polymorphisms with respect to the severity of goiter in patients with untreated Graves disease.

		Graves disease, goiter grade
Polymorphisms, n (%)	Healthy	0	1a	1b	2	3	P value
rs5844572 -794(CATT)n
5	142	4	5	16	84	22	0.979 a
	(36.2)	(33.3)	(31.3)	(36.4)	(31.3)	(39.3)	0.974 b
6	192	5	8	22	134	27
	(49.0)	(41.7)	(50.0)	(50.0)	(50.0)	(48.2)
7	54	3	3	6	47	6
	(13.8)	(25.0)	(18.8)	(13.6)	(17.5)	(10.7)
8	4	0	0	0	3	1
	(1.0)	(0.0)	(0.0)	(0.0)	(1.1)	(1.8)
5/5	19	1	0	3	12	4	0.935 a
	(9.7)	(16.7)	(0.0)	(13.6)	(9.0)	(14.3)	0.984 b
5/6	74	1	3	9	50	10
	(37.8)	(16.7)	(37.5)	(40.9)	(37.3)	(35.7)
5/7	26	1	2	1	9	3
	(13.3)	(16.7)	(25.0)	(4.5)	(6.7)	(10.7)
5/8	4	0	0	0	1	1
	(2.0)	(0.0)	(0.0)	(0.0)	(0.7)	(3.6)
6/6	48	1	2	4	29	8
	(24.5)	(16.7)	(25.0)	(18.2)	(21.6)	(28.6)
6/7	22	2	1	5	25	1
	(11.2)	(33.3)	(12.5)	(22.7)	(18.7)	(3.6)
6/8	0	0	0	0	1	0
	(0.0)	(0.0)	(0.0)	(0.0)	(0.7)	(0.0)
7/7	3	0	0	0	6	1
	(1.5)	(0.0)	(0.0)	(0.0)	(4.5)	(3.6)
7/8	0	0	0	0	1	0
	(0.0)	(0.0)	(0.0)	(0.0)	(0.7)	(0.0)
rs755622 G-173C
G	76	7	4	7	42	7	0.006 a
	(19.4)	(58.3)	(25.0)	(15.9)	(15.7)	(12.5)	0.002 b
C	316	5	12	37	226	49
	(80.6)	(41.7)	(75.0)	(84.1)	(84.3)	(87.5)
G/G	128	1	4	16	95	21	0.009 a
	(65.3)	(16.7)	(50.0)	(72.7)	(70.9)	(75.0)	0.001 b
G/C	60	3	4	5	36	7
	(30.6)	(50.0)	(50.0)	(22.7)	(26.9)	(25.0)
C/C	8	2	0	1	3	0
	(4.1)	(33.3)	(0.0)	(4.5)	(2.2)	(0.0)

Abbreviations: MIF, macrophage migration inhibitory factor.

^aComparisons among healthy individuals and the five groups of different severity of goiter.

^bComparisons among the five groups of different severity of goiter.