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. 2014 Mar 25;9(3):e92952. doi: 10.1371/journal.pone.0092952

Figure 4. TRAIL-/-ApoE-/- mice show impaired glucose and insulin tolerance and kidneys have altered insulin signalling.

Figure 4

(a) Glucose and (b) insulin tolerance tests of ApoE-/- (open circles) and TRAIL-/-ApoE-/- (▪) mice (n = 6–11/genotype). mRNA levels for (c) GLUT2, (d) GLUT4 and (e) insulin receptor were measured in the kidney. All mRNA levels were normalized to β-actin; n = 5-6/genotype. Results expressed as mean ± SEM, *p<0.05, **p<0.01, ***p<0.001 and ****p<0.0001 by Mann-Whitney U test and ANOVA.