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. 2014 Mar 25;9(3):e93179. doi: 10.1371/journal.pone.0093179

Figure 4. Effects of NX210 on functional recovery after SCI: BBB score.

Figure 4

Functional recovery was assessed once a week over the month of the study using the open-field locomotion test and the BBB score. NX210-treated group (n = 8) in solid red line, vehicle group (n = 8) in blue dashed line. (A) The NX210-treated group BBB score was significantly higher in the last two weeks of observation compared to the vehicle group. BBB score continues to improve at the end of the study whereas in the control group, the BBB does not significantly improve from D14 to the end of the study. (B) The percentage of animals reaching a score superior to 14, corresponds to a complete forelimb – hind limb coordination. In the NX210-treated group, the animals reached a score >14 as early as the second week post-injury. The number of animals reaching a BBB score of 14 continuously increases until the end of the study reaching 62% of the NX210-treated group. In the vehicle-treated group, a score>14 is reached by only one animal at the fourth week post-injury. Data are presented as mean ± SEM, p<0.05.