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. 2014 Mar 25;9(3):e93179. doi: 10.1371/journal.pone.0093179

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© 2014 Sakka et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Data are expressed as the percentage of animals providing a normal response to the tests (A) Toe spread. (B) Paw placement. Compared to pre-injury values, NX210-treated rats (n = 8) and vehicle-treated rats (n = 8) showed a significant impairment in both tests the day following the injury. However, at D21 and D28 post-injury, the NX210-treated group showed a significant improvement. Considering toe spread reflex, animals of the vehicle group reach a plateau at D21 whereas in the NX210 treated group, all the animals recover at the end of the study. Data are presented as group mean ± SEM. * significantly different from vehicle group, p<0.05.