Table 1. Meta-analyses of categorical studies of genetic associations with aggression.
Gene | N | OR | 95% CI | P-value | p(Q) | I2(%) | 95% CI |
---|---|---|---|---|---|---|---|
HTR1B | 5 | 0.86 | 0.60–1.23 | 0.42 | 0.06 | 56 | 0–83 |
5HTTLPR | 19 | 0.90 | 0.74–1.09 | 0.29 | 0 | 66 | 45–79 |
5HTT-VNTR | 3 | 1.18 | 0.89–1.58 | 0.26 | 0.80 | 0 | 0–53 |
BDNF | 4 | 0.86 | 0.65–1.13 | 0.27 | 0.20 | 35 | 0–77 |
COMT | 19 | 0.84 | 0.63–1.02 | 0.08 | 0 | 64 | 41–78 |
SLC6A3a | 3 | 1.19 | 0.91–1.56 | 0.20 | 0.92 | 0 | 0 |
DRD4a | 4 | 1.40 | 0.87–2.26 | 0.17 | 0.09 | 53 | 0–85 |
MAOA-F | 5 | 0.96 | 0.64–1.45 | 0.86 | 0.33 | 13 | 0–82 |
MAOA-M | 17 | 0.82 | 0.65–1.05 | 0.13 | 0.01 | 50 | 13–71 |
TPH1 | 5 | 1.19 | 0.92–1.54 | 0.18 | 0.05 | 58 | 0–84 |
AR (CAG) | 3 | 3.04 | 0.94–9.84 | 0.06 | 0 | 91 | 76–97 |
DRD2 | 3 | 1.30 | 0.99–1.71 | 0.06 | 0.26 | 25 | 0–92 |
Abbreviations: CI, confidence interval; I, I2 test for heterogeneity; MAOA-F and MAOA-M, MAOA in females and males, respectively; N, number of studies included; OR, pooled odds ratio; p(Q), P-value of Cochran's Q test for heterogeneity.
Genotypic analysis of the dominant model for SLC6A3 and DRD4.