Table 1. Ligand binding properties of CCR4 expressing cells in heterologous competition binding assays.
Mean IC50 values are from at least three experiments.
| Hot Tracer ligand | ||||
|---|---|---|---|---|
| 125I-CCL17 | 125I-CCL22 | |||
| Cold Competitor |
IC50 CCL17 (nM) |
IC50 CCL22 (nM) |
IC50 CCL17 (nM) |
IC50 CCL22 (nM) |
| CEM-4 | 2.5 ± 0.8 | 2.1 ± 0.8 | 3.8 ± 0.8 | 3.5 ± 0.7 |
| L1.2 CCR4 | 3.1 ± 0.8 | 3.2 ± 0.8 | 4.1 ± 0.7 | 1.5 ± 0.8 |