Table 2.

Significant GWAS findings (p < 5e-8) for HbA_1c in the LLFS with replication information from the ARIC and HABC.

SNP	Chr	Position	Gene	AL^*	LLFS EAF^*	Beta	SE	r²	P	ARIC AL^*	EAF^*	Beta	SE	P	HABC AL^*	EAF^*	Beta	SE	P
No BMI-adj.
rs730497	7	44223721	GCK	A/G	.17	.16	.03	.008	5.9e-8	A/G	.18	.05	.01	3.1e-9	G/A	.84	.01	.03	.81
rs2908282	7	44248828	YKT6	A/G	.17	.16	.03	.008	8.4e-9	A/G	.18	.05	.01	2.2e-9	G/A	.84	.003	.03	.93
rs17476364	10	71094504	HK1	T/C	.90	.27	.04	.011	1.8e-11	G/A ^‡	.88	.07	.01	2.9e-13	T/C	.90	−.01	.04	.73
BMI-Adj.
rs730497 ^†	7	44223721	GCK	A/G	.17	.16	.03	.007	4.6e-7	A/G	.18	.05	.01	4.1e-9	G/A	.84	.003	.03	.92
rs2908282 ^†	7	44248828	YKT6	A/G	.17	.16	.03	.007	5.9e-7	A/G	.18	.05	.01	2.9e-9	G/A	.84	−.001	.03	.97
rs17476364	10	71094504	HK1	T/C	.90	.28	.04	.012	2.7e-11	G/A ^‡	.88	.07	.01	9.6e-14	T/C	.90	−.01	.04	.78
rs72805692	10	71099109	HK1	A/G	.89	.25	.04	.013	2.2e-11	G/A ^‡	.88	.07	.01	9.6e-14	A/G	.89	−.01	.04	.72
rs10159477	10	71099888	HK1	A/G	.16	−.18	.03	.009	3.1e-8	G/A	.88	.07	.01	9.6e-14	G/A	.85	−.01	.03	.78

AL, effect allele / non-effect allele; EAF, effect allele frequency.

^†

SNPs significant for HbA_1c without BMI adjustment but non-significant for HbA_1c with BMI adjustment.

^‡

Same SNP rs10159477 used as best proxy for rs17476364 and rs72805692 (r² = 0.71) in the ARIC.