. Author manuscript; available in PMC: 2015 Mar 1.

Published in final edited form as: Microbes Infect. 2013 Nov 27;16(3):244–252. doi: 10.1016/j.micinf.2013.11.009

Table 2.

Disease burden, yields of C. muridarum IFU recovered from the lungs and Cm-specific IgA and IFN-γ in the lungs at day 10 p.c.

Vaccine	D10 BWC^{^} (%) Mean ± 1SE	IFN-γ in lungs (pg/ml) Mean ± 1SE	IgA in lungs (OD_405nm) Mean ± 1SE	#IFU in lungs Median (Min-Max) ×10⁶
MOMP/P/C-1	−3.12 ± 0.85^a	387 ± 169^a, ^e	1.699 ± 0.177^a, ^e, ^f	0.74 (BLD^* – 15)^h, ⁱ, ^j
MOMP/M^s/C-1	−5.35 ± 0.78^b	1875 ± 418^b	0.496 ± 0.017^b	1.6 (BLD – 21.5)^k
Ng-PorB/P/C-1	−17.41 ± 1.71	12,620 ± 2160	0.349 ± 0.011	442 (0.52 – 4366)
Ng-PorB/M^s/C-1	−10.62 ± 1.39	11,557 ± 2285	0.358 ± 0.01	44.9 (0.46 – 436.6)
MOMP/P/C-2	−6.03 ± 1.50^c	584 ± 151^c	0.809 ± 0.032^c	0.66 (0.37 – 177.6)^l
MOMP/M^s/C-2	−5.11 ± 1.01^d	201 ± 40^d, ^g	0.674 ± 0.039^d, ^g	0.14 (0.02 – 146)^m
Ng-PorB/P/C-2	−19.57 ± 1.93	5736 ± 1872	0.286 ± 0.013	125.8 (3.6 – 5161.5)
Ng-PorB/M^s/C-2	−15.43 ± 1.59	2686 ± 429	0.298 ± 0.01	94.4 (7 – 3792.5)
EB	0.19 ± 0.66	94.4 ± 11.9	2.315 ± 0.083	BLD (BLD – 0.00045)
MEM-0	−22.31 ± 1.62	1929 ± 315	0.241 ± 0.020	209 (24.8 – 2442)

^{^}

, BWC: body weight change;

, BLD: below limit of detection.

, p < 0.05 by the Student's t-test compared with the group immunized with Ng-PorB/P/C-1.

, p < 0.05 by the Student's t-test compared with the group immunized with Ng-PorB/M^s/C-1.

, p < 0.05 by the Student's t-test compared with the group immunized with Ng-PorB/P/C-2.

, p < 0.05 by the Student's t-test compared with the group immunized with Ng-PorB/M^s/C-2.

, p < 0.05 by the Student's t-test compared with the group immunized with MOMP/M^s/C-1.

, p < 0.05 by the Student's t-test compared with the group immunized with MOMP/P/C-2.

, p < 0.05 by the Student's t-test compared with the groups immunized with MOMP/M^s/C-1 or with MOMP/P/C-2.

, p < 0.05 by the Mann Whitney's U-test compared with the groups immunized with Ng-PorB/P/C-1 or with MOMP/P/C-2.

ⁱ

, p =0.05 by the Mann Whitney's U-test compared with the group immunized with MOMP/M^s/C-1.

, p =0.069 by the Mann Whitney's U-test compared with the group immunized with MOMP/M^s/C-2.

, p < 0.05 by the Mann Whitney's U-test compared with the group immunized with Ng-PorB/M^s/C-1.

, p < 0.05 by the Mann Whitney's U-test compared with the group immunized with Ng-PorB/P/C-2.

, p < 0.05 by the Mann Whitney's U-test compared with the group immunized with Ng-PorB/M^s/C-2.