Table 1.

Molecular targets of sulindac sulfide and tolfenamic acid in different cancer types.

NSAIDs	Up- regulated targets	Down- regulated targets	Cancer types [References]
Sulindac sulfide	EGR-1		Colon [80], Lung [13], brain [95]
	ATF3		Colon [20]
		NF-κB	Colon [46], Breast [96]
	NF-κB		Colon [50]
		β-catenin	Colon [53], lung and breast [97]
		EGFR	Colon [61]
	E-cadherin		Colon [63]
		PDE5	Colon [67]
	NAG-1		Colon [74], ovarian [78], Gastric [98], Prostate [99]
		Nesprin-2	Colon [73]
	p21		Breast [92], ovarian [78], Head/Neck [100], Pancreas [101]
	CHOP		Colon [28]
		Cyclin D1	Breast [92], pancreas [101], colon [102]
Tolfenamic acid	EGR-1		Colon [15]
	ATF3		Colon [19]
	ATF4		Colon [9]
	CHOP		Colon [9]
		Sp1	Pancreas [36], Rhabdomyosarcoma [37], lung [38], esophageal [91]. Ovarian [103], colon [40]
	NF-κB		Colon [49]
		Smad2/3	Lung [60]
	NAG-1		Colon [15], Oral [76], thyroid [79]
	p21		Breast [104]
		Cyclin D1	Colon [9]