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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: J Immunol. 2014 Feb 21;192(7):3301–3307. doi: 10.4049/jimmunol.1303049

Figure 4. Macrophage oxidative burst is essential for lung S. aureus clearance.

Figure 4

Numbers of bacteria remaining in the lungs 24 h after MRSA BAA-1695 infection of C57BL/6 (A) WT, NOS2−/−, gp91phox−/−, and p47phox−/− mice, (B) α-PMN antibody-treated WT and gp91phox−/− mice, and (C) Mafia mice. In (B), mice were treated with RB6-8C5 mAb for neutrophil depletion. In (C), Mafia mice were depleted of macrophages using AP20187 dissolved in ethanol. Control WT mice were also treated with AP20187. (D) Survival of α-PMN antibody-treated WT mice after i.n. infection with 108 CFU of MRSA. Control WT mice were treated with Rat IgG. (E) Survival of α-PMN antibody-treated WT and gp91phox−/− mice after i.n. infection with 107 CFU of MRSA. In (A, B&C), P<0.001, ANOVA; ***P< 0.001, Tukey’s multiple comparisons test.