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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Int J Antimicrob Agents. 2013 Dec 17;43(3):223–230. doi: 10.1016/j.ijantimicag.2013.11.006

Fig. 1.

Fig. 1

Pharmacokinetic/pharmacodynamic (PK/PD) relationships between antibiotic concentrations relative to the minimum inhibitory concentration (MIC) over time. Three principle PK/PD parameters most often correlate with the clinical efficacy of different antibiotic classes: (1) maximum concentration (Cmax)/MIC ratio for concentration-dependent drugs; (2) percentage of the dosing interval above the MIC (T>MIC) for time-dependent drugs with minimal-to-no persistent effects; and (3) area under the concentration–time curve (AUC, shaded area)/MIC ratio for time-dependent drugs with moderate-to-prolonged persistent effects.