Table 2.
Expt | Group | Condition | Rat number
|
|||||
---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | |||
1 | ER | T | 91 | 97 | 84 | 96 | 89 | -- |
saline | 84(71–97) | 98(98–98) | 46(36–62) | 95(90–98) | 51(27–81) | -- | ||
0.10 hist | 60 | 98 | 23 | 80 | 68 | -- | ||
0.32 hist | 97 | 98 | 55 | 48 | 45 | -- | ||
1.00 hist | 7 | 96 | 33 | 90 | 51 | -- | ||
RP | T | 60 | 32 | 97 | 98 | 90 | -- | |
saline | 98(98–98) | 98(95–98) | 68(42–83) | 98(98–98) | 88(72–96) | -- | ||
0.10 hist | 98 | 97 | 96 | 98 | 98 | -- | ||
0.32 hist | 56 | 28 | 20 | 98 | 91 | -- | ||
1.00 hist | 93 | 37 | 30 | 98 | 85 | -- | ||
DR | T | 98 | 55 | 98 | 39 | 43 | 98 | |
saline | 98(98–98) | 98(98–98) | 98(98–98) | 98(98–98) | 98(98–98) | 98(98–98) | ||
0.10 hist | 98 | 98 | 98 | 98 | 98 | 98 | ||
0.32 hist | 72 | 88 | 72 | 51 | 80 | 95 | ||
1.00 hist | 28 | 91 | 23 | 62 | 90 | 80 | ||
2 | Pyrilamine (DR) | T | 98 | 77 | 96 | 98 | 98 | -- |
sal + sal | 98(98–98) | 98(95–98) | 98(97–98) | 98(98–98) | 98(98–98) | -- | ||
hist + sal | 92(92–92) | 87(80–93) | 38(16–60) | 90(87–93) | 93(91–95) | -- | ||
hist + 0.10 | 87 | 79 | 98 | 76 | 86 | -- | ||
hist + 0.32 | 89 | 81 | 79 | 78 | 98 | -- | ||
hist + 1.00 | 97 | 66 | 73 | 78 | 97 | -- | ||
hist + 3.20 | 94 | 87 | 93 | 87 | 92 | -- | ||
Ketotifen (DR) | T | 97 | 86 | 21 | 87 | 36 | -- | |
sal + sal | 96(90–98) | 82(50–98) | 48(18–98) | 91(64–98) | 79(20–98) | -- | ||
hist + sal | 15(9–21) | 24(10–38) | 11(10–12) | 37(18–56) | 23(2–43) | -- | ||
hist + 0.01 | 37 | 80 | 39 | 40 | 43 | -- | ||
hist + 0.10 | 55 | 60 | 38 | 82 | 68 | -- | ||
hist + 1.00 | 49 | 11 | 18 | 25 | 17 | -- | ||
Ranitidine (DR) | T | 98 | 96 | 98 | 83 | 71 | -- | |
sal + sal | 98(98–98) | 98(98–98) | 98(98–98) | 97(97–98) | 98(98–98) | -- | ||
hist + sal | 90(85–96) | 38(29–45) | 27(19–41) | 37(13–82) | 50(42–61) | -- | ||
hist + 3.2 | 86 | 42 | 35 | 6 | 63 | -- | ||
hist + 5.6 | 96 | 42 | 27 | 36 | 70 | -- | ||
Pyrilamine (ER) | T | 94 | 98 | 98 | 98 | 91 | -- | |
sal + sal | 98(98–98) | 97(94–98) | 98(98–98) | 98(98–98) | 98(98–98) | -- | ||
hist + sal | 78(66–89) | 72(62–81) | 51(26–75) | 92(91–92) | 77(69–85) | -- | ||
hist + 0.10 | 90 | 92 | 60 | 98 | 81 | -- | ||
hist + 0.32 | 94 | 94 | 98 | 98 | 96 | -- | ||
hist + 1.00 | 98 | 89 | 74 | 98 | 77 | -- | ||
hist + 3.20 | 94 | 95 | 92 | 98 | 95 | -- | ||
Ketotifen (ER) | T | 94 | 95 | 66 | 97 | 53 | -- | |
sal + sal | 98(98–98) | 98(98–98) | 96(88–98) | 98(98–98) | 87(70–98) | -- | ||
hist + sal | 72(46–98) | 74(66–82) | 74(60–87) | 68(62–73) | 57(29–84) | -- | ||
hist + 0.01 | 98 | 67 | 61 | 28 | 85 | -- | ||
hist + 0.10 | 75 | 73 | 93 | 68 | 83 | -- | ||
hist + 1.00 | 46 | 82 | 60 | 73 | 29 | -- |
Note. Ranges are indicated in parentheses.