. 2014 Apr;349(1):94–98. doi: 10.1124/jpet.113.209353

TABLE 1.

Plasma biochemistry in wild-type and Mdr2 knockout mice

Data are the mean ± S.D.

	Mdr2^+/+ Mice	Mdr2^+/− Mice	Mdr2^−/− Mice
	Control Diet  (n = 7)	Control Diet  (n = 7)	Control Diet  (n = 12)	UDCA  (n = 11)	atRA  (n = 12)	UDCA and atRA  (n = 12)
ALT (U/L)	42 ± 7	52 ± 17	294 ± 86^a	376 ± 134^a	238 ± 99^a	273 ± 34^a
ALP (U/L)	72 ± 6	78 ± 8	204 ± 29^a	190 ± 38^a	172 ± 24^a^,^b	173 ± 24^a^,^b
Plasma bile acid (µM)	17 ± 15	12 ± 9	46 ± 16^a	23 ± 2^a^,^b	24 ± 4^a^,^b	20 ± 9^a^,^b
Liver bile acid (µM)	118 ± 94	102 ± 72	329 ± 47^a	236 ± 36^a^,^b	299 ± 115^a	235 ± 74^a^,^b

P < 0.05 to Mdr2^+/+ wild type

P < 0.05 to Mdr2^−/− control diet.