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. 2014 Apr;349(1):21–28. doi: 10.1124/jpet.113.211144

Fig. 6.

Fig. 6.

Effect of Tempol (0.4 mM) on force development in the presence of isoflurane in control and ZDF muscles at stimulation frequency of 0.5 Hz (A) and 1.5 Hz (B). Isoflurane decreased force development in both control and ZDF muscles. Tempol did not affect the isoflurane-induced force depression in control muscles. However, Tempol inhibited the force-depressing effect of isoflurane in ZDF muscles. *P < 0.01 versus in the absence of isoflurane in the control group; #P < 0.01 versus in the absence of isoflurane in ZDF group; **P < 0.05 versus in the absence of Tempol in the ZDF group. N = 4, extracellular [Ca2+] = 1.0 mM.