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. 2014 Apr;42(4):665–674. doi: 10.1124/dmd.113.054304

Fig. 3.

Fig. 3.

Logistic regression curves for estimated probability of cholestatic potential based on the percent MRP4 inhibition among BSEP non-inhibitors (A) and BSEP inhibitors (B). The bold curves show the estimated probability of cholestasis, and the shaded areas represent 95% confidence intervals. The symbols denote the observed percent MRP4 inhibition values for cholestatic (values = 1.00) and non-cholestatic (values = 0.00) drugs. The inset shows the estimated odds ratios with 95% confidence intervals for different MRP4 inhibition values (e.g., a compound exhibiting 35% MRP4 inhibition has 2.9-fold greater odds of being cholestatic).