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. Author manuscript; available in PMC: 2015 Feb 14.
Published in final edited form as: Circ Res. 2013 Dec 3;114(4):660–671. doi: 10.1161/CIRCRESAHA.114.302931

Figure 2. Introgression of Dce1 into the Bc genome rescues cerebral infarct volume.

Figure 2

Cortical infarctions were produced in 2–3 mos-old CNG3, CNG5 and wild-type mice by permanent MCAO.16,18 24 hours later, brains were sectioned (1mm) and TTC-stained to reveal non-viable tissue (white). Sections from the same brain level are shown. Infarct volumes expressed as % of total brain volume were determined from the complete set of sections in each brain. Within each genotype, CNG3, CNG4 and CNG5 are not significantly different even though the introgressed regions in CNG3 and CNG4 extend beyond that in CNG5 and include the EMMA peak (Figure 1A). This supports the conclusion that the causal element for infarct volume, as for pial collateral number and diameter, lies in Dce1. The B6/B6 genotype in CNG3, CNG4, and CNG5 rescues 85% of the difference between wildtype B6 and Bc.