Table 2. Enriched in neurons.
|
BP neurons |
Control neurons |
|||
|---|---|---|---|---|
| GO term | n | P*⩽ | n | P*⩽ |
| Synapse | 183 | 2.1 × 10−22 | 180 | 1.5 × 10−21 |
| Neuron projection | 173 | 3.4 × 10−20 | 176 | 1.2 × 10−21 |
| Neuron development | 161 | 4.5 × 10−12 | 167 | 7.2 × 10−15 |
| Voltage-gated cation channel activity | 66 | 7.8 × 10−4 | 61 | 1.6 × 10−2 |
Abbreviation:
BP, bipolar disorder;
GO, Gene Ontology; *, Bonferroni correction.
Neurons differentiated from BP and control iPSC expressed similar sets of transcripts, many associated with neuronal differentiation, synapses and channel activity.