Table 3. Analysis of iPSCs.

i. Increased in BP iPSC			ii. Increased in C iPSC
GO term	n	P*⩽	GO term	n	P*⩽
Embryonic morphogenesis	17	9.0 × 10−5	TGFβ related	4	5.7 × 10−4
Signal	57	6.1 × 10−4
Axonogenesis	10	9.4 × 10−3
Appendage development	8	6.7 × 10−3
Skeletal system development	12	1.7 × 10−2
Cell adhesion	20	6.7 × 10−3
Female gonad development	7	6.1 × 10−3
Skeletal system morphogenesis	7	3.0 × 10−2
Positive regulation of developmental process	13	4.9 × 10−3
Cell–cell adhesion	10	4.9 × 10−2
Transcription from PolII	18	3.0 × 10−2
Blood vessel development	10	2.8 × 10−2
Transcription regulation	36	2.2 × 10−2
Tube development	9	4.5 × 10−2

Abbreviations: BP, bipolar disorder; C, control; GO, Gene Ontology; iPSC, induced pluripotent stem cells; TGFβ, transforming growth factor-β  *, Bonferroni correction. i: Functional Annotation Cluster analysis identified 14 clusters of transcripts that were expressed at significantly higher levels in BP vs control iPSC, most associated with early development. ii: A single cluster of transforming growth factor-β-related transcripts was expressed at significantly higher levels in control iPSC.