Skip to main content
. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Nat Chem Biol. 2013 Dec;9(12):776–784. doi: 10.1038/nchembio.1403

Figure 4. Properties of the three-component cancer vaccine.

Figure 4

(a) Chemical structure of synthetic vaccine. (b) Left, glycosylated multi-component vaccine reduces MMT tumor burden in MUC1.Tg mice. MUC1.Tg mice were immunized with empty liposomes (EL) as control or with liposomes containing the vaccine. Three biweekly immunizations were given before a tumor challenge with MUC1-expressing MMT tumor cells followed by one boost one week after. Middle, induction of antibody-dependent cell-mediated cytotoxicity (ADCC). Right, induction of CD8+ cytolytic T cells in MUC1.Tg mice. Reprinted with permission from reference 79. Each data point represents an individual mouse, and the horizontal lines indicate the mean for the group of mice.