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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Nat Chem Biol. 2013 Dec;9(12):776–784. doi: 10.1038/nchembio.1403

Figure 5. Galectins can reorganize cell surface receptors by binding their glycans.

Figure 5

Galectin-3 can organize the TCR and CD45 of T cells into lattices by binding their glycans. In this way, galectin-3 is proposed to block direct interactions of TCRs. Furthermore, the phosphatase activity of CD45 causes downregulation of T-cell signaling.