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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: J Pathol. 2014 Jan;232(1):75–86. doi: 10.1002/path.4283

Figure 1.

Figure 1

Integrative analyses of public genomics data reveal MAP3K3 as a potential oncogene target in breast cancers. (A) ConSig score revealing primary oncogene targets of genomic amplifications in 17q. The x axis shows 107 candidate genes sorted by their physical locations in the chromosome. Red bars show the frequency of genomic amplification for each candidate gene. ConSig scores are shown in the blue line chart, with the spikes indicating biologically important genes. The top 10 candidate genes benchmarked by ConSig score are labelled on the x axis, with the cut-off shown by the dashed line. (B) List of the top 10 candidate genes by integrative analysis of public genomic datasets. (C) A physical map of the chromosome 17q23 region, with MAP3K3 indicated in red.