Table 1.
eIF4G homologs across species with MIF4G region identified by amino acid location.
| Sequence Name (Amino Acid Length) |
Binding Domain |
Region | Reference |
|---|---|---|---|
| eIF4G-I/eIF4G1 Human (1599) | MIF4G | 565–792 | Uniprot: Q04637 |
| Isoform 1 (1600) | MIF4G | 762–987 | NCBI: NP_886553.3 |
| Isoform 2 (1512) | MIF4G | 674–899 | NCBI: NP_937887.1 |
| Isoform 3 (1435) | MIF4G | 597–822 | NCBI: NP_937885.1 |
| Isoform 4 (1404) | MIF4G | 566–791 | NCBI: NP_004944.3 |
| Isoform 5 (1599) | MIF4G | 761–986 | NCBI: NP_937884.1 |
| Isoform 6 (1606) | MIF4G | 768–993 | NCBI: NP_001181875.1 |
| Predicted Isoform X3 (1600) | MIF4G | 762–987 | NCBI: XP_005247244.1 |
| Predicted Isoform X4 (1600) | MIF4G | 762–987 | NCBI: XP_005247245.1 |
| Predicted Isoform X12 (1404) | MIF4G | 566–791 | NCBI: XP_005247253.1 |
| Predicted Isoform X13 (1404) | MIF4G | 566–791 | NCBI: XP_005247254.1 |
| eIF4G-II/eIF4G3 Human (1585) | MIF4G | 755–983 | Uniprot: O43432 |
| Isoform 1 (1621) | MIF4G | 791–1016 | NCBI: NP_001185730.1 |
| Isoform 2 (1591) | MIF4G | 761–986 | NCBI: NP_001185731.1 |
| Isoform 3 (1585) | MIF4G | 755–980 | NCBI: NP_003751.2 |
| Isoform 4 (515) | NCBI: NP_001185732.1 | ||
| eIF4G-I/eIF4G1 Mouse (1600) | MIF4G | 765–993 | Uniprot: Q6NZJ6 |
| Isoform A (1600) | MIF4G | 765–993 | NCBI: NP_666053.2 |
| Isoform B (1593) | MIF4G | 758–986 | NCBI: NP_001005331.1 |
| eIF4G-II/eIF4G3 Mouse (1579) | MIF4G | 750–978 | Uniprot: Q80XI3 |
| Isoform 1 (1578) | MIF4G | 768–993 | NCBI: NP_766291.2 |
| Isoform 2 (1567) | MIF4G | 757–982 | NCBI: NP_001243124.1 |
| Isoform 3 (1464) | MIF4G | 757–982 | NCBI: NP_001243127.1 |
| eIF4G-I/eIF4G1 Rabbit (1402) | MIF4G | 567–793 | NCBI: P41110.1 |
| eIF4G-II/eIF4G3 Rabbit (1579) | Uncharacterized | Uniprot: G1SHL6 | |
| IFG-1 p170 C. elegans (1156) | MIF4G | 518–748 | Uniprot: Q21531 |
| Isoform A (1156) | MIF4G | 518–748 | NCBI: CAA90261.1 |
| Isoform B (1155) | MIF4G | 517–747 | NCBI: CAE47470.1 |
| Isoform C (1042) | MIF4G | 404–634 | NCBI: CAR31495.1 |
| Isoform D (734) | MIF4G | 96–326 | NCBI: NP_001129820 |
| Isoform E (688) | MIF4G | 50–280 | NCBI: CAR31497.1 |
| IFG-1 p130 C. elegans (765) | MIF4G | 127–357 | (Contreras et al., 2011) |
| eIF4G-I/eIF4G1 Fruit Flya (1666) | MIF4G | 751–999 | NCBI: AAC38985.1 |
| Isoform A (1666) | MIF4G | 751–999 | NCBI: AAF59403.3 |
| Isoform B (1919) | MIF4G | 1004–1252 | NCBI: ABV53593.1 |
| Isoform C (1666) | MIF4G | 751–999 | NCBI: NP_001137857.1 |
| Tif4631 Yeastb (952) | MIF4G | 607–850 | Uniprot: P39935 |
| Tif4632 Yeastb (914) | MIF4G | 567–810 | Uniprot: P39936 |
| eIF4G1 Wheatc (1488) | MIF4G | 883–1106 | Uniprot: G5CEW6 |
| eIFiso4G1 Wheatc (788) | MIF4G | 211–436 | Uniprot: Q03387 |
| eIFiso4G2 Wheatc (787) | MIF4G | 210–435 | Uniprot: Q41583 |
| eIF4G Arabidopsisd (1727) | MIF4G | 1096–1319 | NCBI: AEE80028.1 |
| eIFiso4G1 Arabidopsisd (780) | MIF4G | 216–440 | NCBI: Q93ZT6.1 |
| eIFiso4G2 Arabidopsisd (747) | MIF4G | 176–400 | NCBI: O82233.1 |
a
Drosophila melanogaster,
b
Saccharomyces cerevisiae,
c
Triticum aestivum,
d
Arabidopsis thaliana