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. Author manuscript; available in PMC: 2014 Mar 26.
Published in final edited form as: J Huntingtons Dis. 2013 Jun 18;2(1):201–215. doi: 10.3233/JHD-130058

Fig.2. Deletion of ataxin-3 does not alter age-dependent changes in neurotransmitter receptor expression in HdhQ200 mice.

Fig.2

Littermates from all four genotypes (n=4/group) were assessed at 60 weeks of age for expression of specific neurotransmitter receptors in different brain regions, measured by autoradiography. As previously reported [27], compared to wild type mice HdhQ200 mice show a significant decrease in D1 receptor binding in striatum, nuclear accumbens (nAcc) and olfactory tubercle (Olf Tub). A significant increase in striatal GABAA receptor binding in HdhQ200 mice has not been previously reported. One-way ANOVA with Bonferroni post hoc established that D1 receptor (A, B), D2 receptor (data not shown) and GABAA receptor (C, D) expression does not differ significantly between HdhQ200/Atxn3+/+ and HdhQ200/Atxn3-/- mice. Error bars represent SEM. *p<0.05, **p<0.01, ***p<0.001 and ns = no significance.