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. 2014 Mar;33(3):148–158. doi: 10.5732/cjc.013.10095

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Chinese Journal of Cancer

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.

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Figure 8. — Tumor neovascularization is observed after staining for von-Willebrand factor (vWF) (40× magnification) in baseline, nonirradiated, and irradiated tumors (upper panel). Fluorescein isothiocyanate (FITC)-tagged lectin staining also shows neovascularization in baseline, nonirradiated, and irradiated tumors (middle panel). vWF-positive areas are seen crossing the midline along the corpus callosum in rats receiving radiation (10× magnification) (lower panel). Although irradiated tumors exhibit a relative increase in the number of vessels, analysis of mean microvessel density did not reveal any significant changes in irradiated tumors compared with baseline or nonirradiated tumors.