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Study design. The ventilatory parameters were evaluated by plethysmographic approach in non‐anesthetized and unrestrained mice exposed to either chronic normoxic (NX‐exposed) or hypoxic (HX‐exposed) conditions. The acute ventilatory response to hypoxia was checked by replacing air (control) by hypoxic gas mixture (hypoxia, O2 8 %, 5 min) before (vehicle) and after drug injection.
