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. Author manuscript; available in PMC: 2014 Mar 26.
Published in final edited form as: J Exp Bot. 2011 Dec 26;63(4):1525–1542. doi: 10.1093/jxb/err394

Fig. 3. Conserved regulators of mitochondrial Ca2+ import between humans and plants.

Fig. 3

(A) Alignment of the transmembrane domain of the human mitochondrial calcium uniporter (MCU, gi24308400) with its six homologues from Arabidopsis thaliana displays the two transmembrane helices (TM1 and TM2) connected by a highly conserved loop domain containing the amino acids DIME in human and DVME in Arabidopsis. (B) Overview of targeting and expression of the MCU homologues. The cladogram displays the homology relationship between the Arabidopsis proteins. The blast e-value for each protein relative to the human MCU is written in parentheses after the Arabidopsis gene identifier (AGI). Protein localization was predicted by Aramemnon (Schwacke et al., 2003) and the meta-score is indicated in parentheses. Organ-related RNA expression profiles were examined with the help of the GENEVESTIGATOR browser (Zimmermann et al., 2004) and the presence of expressed sequence tags (ESTs) in the TAIR 10 database (www.arabidopsis.org).