Table 5.

Survival outcomes – Association of 2 minute walk test and hand grip strength with overall survival and non-relapse mortality

Outcome	Measure	p-value	HR	95% CI
At enrollment
OS	2MWT	0.002	0.996	0.994	0.999
	HGS	0.95	0.999	0.983	1.017
NRM	2MWT	0.003	0.996	0.993	0.999
	HGS	0.87	1.002	0.981	1.023
FFS	2MWT	0.07	0.999	0.998	1.000
	HGS	0.28	1.006	0.995	1.016
Time-varying
OS	2MWT	<0.001	0.995	0.993	0.998
	HGS	0.63	0.994	0.969	1.019
NRM	2MWT	0.001	0.994	0.991	0.998
	HGS	0.95	0.999	0.967	1.032
FFS	2MWT	0.01	0.998	0.997	1.000
	HGS	0.76	1.002	0.991	1.013

2MWT grouped as ≤500 vs. >500
Outcome	Group	p-value	HR	95% CI
At enrollment
OS	≤500	0.10	1.51	0.93	2.45
	>500		1
NRM	≤500	0.05	1.93	1.00	3.72
	>500		1
FFS	≤500	0.10	1.24	0.96	1.59
	>500		1
Time-varying
OS	≤500	0.002	2.58	1.41	4.73
	>500		1
NRM	≤500	0.02	2.55	1.17	5.56
	>500		1
FFS	≤500	0.008	1.42	1.10	1.85
	>500

^*HR defines the hazard ratio for overall survival or non-relapse mortality according to increase in the functional test (2 minute walk test or hand grip strength) by one unit.

^*2MWT = 2 minute walk test; HGS = hand grip strength