Extended Data Table 1. Sequences of functional structure mutations.

5’-3’ mRNA structure sequences are listed. Lowercase letters correspond to non-paired bases, found in bulges or loops within the stem. Mutated bases are underlined.

UTR	Stem Sequence (5’ to 3’)
PMA1 Wildtype	TTTTTTCTcTCTTTTatacacacattcAAAAGAaAGAAAAAA
PMA1 Mutant 1	TTTTTTCTcTCTTTTatacacacattcTTTTCTcTCTTTTTT
PMA1 Compensated 1	AAAAAAGAaAGAAAAatacacacattcTTTTCTcTCTTTTTT
PMA1 Mutant 2	TTTTTTCTcTCTTTTatacacacattcAAAttcatttAAAAAA
PMA1 Compensated 2	TTTTTaagcgagTTTatacacacattcAAAttcatttAAAAAA
SFT2 Wildtype	GTTTTTTTTTTTTGctggTAAAAAAAAAGAAC
SFT2 Mutant 1	CAAAAAAAAAAAATctggTAAAAAAAAAGAAC
SFT2 Compensated 1	CAAAAAAAAAAAATctggGTTTTTTTTTTTTG
SFT2 Mutant 2	GTTTTTTTTTTTTGctggTAAAttttttGAAC
SFT2 Compensated 2	GTTTaaaaaaTTTGctggTAAAttttttGAAC
SFT2 Mutant 3	GTTTTTTTTTTTTGctggTAAAccccccGAAC
SFT2 Compensated 3	GTTTggggggTTTGctggTAAAccccccGAAC
PRC1 Wildtype	GCTACGATcgaaATATAtACGTttttatctatgttACGTTATATATTGTAGT
PRC1 Mutant	TGATGTTAcgaaTATATtTGCAttttatctatgttACGTTATATATTGTAGT
PRC1 Compensated	TGATGTTAcgaaTATATtTGCAttttatctatgttTGCAATATATAGCATCG