TABLE 3.

Relationship Between Free Thyroxine 14-Day AUC/42-Day AUC and 7-Year Cognitive Outcomes

Cognitive outcomes	14-Day AUC (unadjusted; n = 83a)			14-day AUC (adjusted; n = 79a)			42-day AUC (unadjusted; n = 83a)			42-day AUC (adjusted; n = 79a)
	β	R2 (%)	p	β	sr2 (%)	p	β	R2 (%)	p	β	sr2 (%)	p
General intellectual ability
FSIQ	0.17	2.9	0.19	−0.08	0.3	0.69	0.09	0.8	0.45	−0.09	0.4	0.61
Language
General language ability	0.02	0.03	0.90	−0.25	2.7	0.17	−0.03	0.09	0.81	−0.20	2.0	0.25
Verbal working memory, learning, and memory
Immediate verbal memory	−0.03	0.09	0.83	−0.40	6.6	0.06	−0.05	0.3	0.57	−0.23	2.6	0.13
Working memory	−0.003	<0.001	0.98	−0.15	0.9	0.48	−0.01	0.01	0.93	−0.04	0.1	0.81
Verbal learning	−0.04	0.2	0.72	−0.42	7.5	0.02	−0.08	0.7	0.42	−0.30	4.5	0.04
Verbal memory	−0.06	0.4	0.61	−0.40	6.5	0.03	−0.13	1.6	0.28	−0.35	6.2	0.06
Spatial working memory, learning, and memory
Immediate spatial memory	−0.07	0.5	0.61	−0.31	4.1	0.11	−0.08	0.7	0.44	−0.12	0.7	0.43
Spatial learning	−0.09	0.9	0.51	−0.26	2.8	0.17	−0.05	0.2	0.60	0.03	0.04	0.85
Spatial memory	−0.11	1.3	0.44	−0.21	1.9	0.21	−0.07	0.5	0.49	0.06	0.2	0.62
Attention and executive functioning
Selective attention	−0.03	0.1	0.80	−0.33	4.4	0.09	−0.11	1.1	0.35	−0.28	4.0	0.06
Sustained attention	0.005	<0.001	0.97	−0.15	0.9	0.35	0.08	0.7	0.46	0.10	0.4	0.56
Shifting attention	0.19	3.7	0.08	0.11	0.5	0.50	0.17	2.9	0.13	0.12	0.8	0.46
Divided attention	0.06	0.4	0.58	−0.07	0.2	0.68	0.04	0.2	0.71	−0.02	0.01	0.90
Planning	0.008	0.01	0.95	−0.19	1.6	0.29	−0.02	0.06	0.82	−0.13	0.8	0.43
Speed of information processing and reaction time
Simple reaction timeb	0.19	3.66	0.13	0.56	13.0	<0.001	0.22	4.7	0.05	0.40	7.7	0.002
Complex reaction timeb	−0.0003	<0.001	0.99	0.24	2.4	0.10	0.05	0.2	0.67	0.21	2.1	0.16

Covariates for adjusted analyses included GA, gender, social risk, duration of IPPV, and neonatal brain injury.

^aSome sample sizes are less than the total sample owing to missing data.

^bTask is reverse-scored, where higher scores signify a slower reaction time.