Table 3.
Use of Xpert® MTB/RIF for screening
| HIV prevalence |
Culture-positive n |
Sensitivity of smear microscopy % (95%CI) |
Sensitivity of Xpert® MTB/RIF % (95%CI) |
||||
|---|---|---|---|---|---|---|---|
| Study | Country | Screening population | % positive | n | |||
| Lawn, 201252 | South Africa | ART clinic | 100 | 515 | 81 | 22.2 (13.3–33.6) | 58.3 (46.1–69.8) |
| O’Grady, 20129 | Zambia | Medical admissions able to produce sputum | 65 | 881 | 201 | 52.8 (45.1–60.4): HIV+ 48.6 (33.0–64.4): HIV− |
88.2 (81.9–92.6): HIV− 74.3 (56.4–87.0): HIV− |
| Dorman, 201249 | South Africa | Prevalence survey | ND | 6893 | 187 | 17.6 (12.5–23.9): HIV+ | 62.6 (55.2–69.5) |
| Ntinginya 201251 | Tanzania | Household contacts | ND | 219 | 5 | 60.0 (14.7–94.7): HIV− | 100 (47.8–100) |
HIV = human immunodeficiency virus; ART = antiretroviral therapy; ND = not done.